A Hardware-in-the-Loop Evaluation of the Impact of the V2X Channel on the Traffic-Safety Versus Efficiency Trade-offs

Vehicles are increasingly becoming connected and short-range wireless communications promise to introduce a radical change in the drivers' behaviors. Among the main use cases, the intersection management is surely one of those that could mostly impact on both traffic safety and efficiency. In this work, we consider an intersection collision warning application and exploit an hardware-in-the-loop (HIL) platform to verify the impact on the risk of accidents as well as the average time to travel a given distance. Besides including real ITS-G5 compliant message exchanges, the platform also includes a channel emulator with real signals. Results show that the risk of collisions can be drastically reduced, with an overall trade-off between safety and traffic efficiency. At the same time, it is shown that the presence of real channel conditions cannot guarantee the same condition of zero-risk as with ideal channel propagation, remarking the importance of channel conditions and signal processing

Seroprevalence of 34 Human Papillomavirus Types in the German General Population

The natural history of infections with many human papillomavirus (HPV) types is poorly understood. Here, we describe for the first time the age- and sex-dependent antibody prevalence for 29 cutaneous and five mucosal HPV types from 15 species within five phylogenetic genera (alpha, beta, gamma, mu, nu) in a general population. Sera from 1,797 German adults and children (758 males and 1,039 females) between 1 and 82 years (median 37 years) were analysed for antibodies to the major capsid protein L1 by Luminex-based multiplex serology. The first substantial HPV antibody reactions observed already in children and young adults are those to cutaneous types of the genera nu (HPV 41) and mu (HPV 1, 63). The antibody prevalence to mucosal high-risk types, most prominently HPV 16, was elevated after puberty in women but not in men and peaked between 25 and 34 years. Antibodies to beta and gamma papillomaviruses (PV) were rare in children and increased homogeneously with age, with prevalence peaks at 40 and 60 years in women and 50 and 70 years in men. Antibodies to cutaneous alpha PV showed a heterogeneous age distribution. In summary, these data suggest three major seroprevalence patterns for HPV of phylogenetically distinct genera: antibodies to mu and nu skin PV appear early in life, those to mucosal alpha PV in women after puberty, and antibodies to beta as well as to gamma skin PV accumulate later in life

Racial differences in systemic sclerosis disease presentation: a European Scleroderma Trials and Research group study

Objectives. Racial factors play a significant role in SSc. We evaluated differences in SSc presentations between white patients (WP), Asian patients (AP) and black patients (BP) and analysed the effects of geographical locations.Methods. SSc characteristics of patients from the EUSTAR cohort were cross-sectionally compared across racial groups using survival and multiple logistic regression analyses.Results. The study included 9162 WP, 341 AP and 181 BP. AP developed the first non-RP feature faster than WP but slower than BP. AP were less frequently anti-centromere (ACA; odds ratio (OR) = 0.4, P < 0.001) and more frequently anti-topoisomerase-I autoantibodies (ATA) positive (OR = 1.2, P = 0.068), while BP were less likely to be ACA and ATA positive than were WP [OR(ACA) = 0.3, P < 0.001; OR(ATA) = 0.5, P = 0.020]. AP had less often (OR = 0.7, P = 0.06) and BP more often (OR = 2.7, P < 0.001) diffuse skin involvement than had WP.AP and BP were more likely to have pulmonary hypertension [OR(AP) = 2.6, P < 0.001; OR(BP) = 2.7, P = 0.03 vs WP] and a reduced forced vital capacity [OR(AP) = 2.5, P < 0.001; OR(BP) = 2.4, P < 0.004] than were WP. AP more often had an impaired diffusing capacity of the lung than had BP and WP [OR(AP vs BP) = 1.9, P = 0.038; OR(AP vs WP) = 2.4, P < 0.001]. After RP onset, AP and BP had a higher hazard to die than had WP [hazard ratio (HR) (AP) = 1.6, P = 0.011; HR(BP) = 2.1, P < 0.001].Conclusion. Compared with WP, and mostly independent of geographical location, AP have a faster and earlier disease onset with high prevalences of ATA, pulmonary hypertension and forced vital capacity impairment and higher mortality. BP had the fastest disease onset, a high prevalence of diffuse skin involvement and nominally the highest mortality

Partial Equalization for MC–CDMA Systems in Non-Ideally Estimated Correlated Fading

Multicarrier code-division multiple access (MC–CDMA) can support high data rates in next-generation multiuser wireless communication systems. Partial equalization (PE) is a low-complexity technique for combining the signals of subcarriers to improve the achievable performance of MC–CDMA systems in terms of their bit error probability (BEP) and bit error outage (BEO) in comparison with maximal ratio combining, orthogonality restoring combining, and equal-gain combining techniques. We analyze the performance of the multiuser MC–CDMA downlink and derive the optimal PE parameter expression, which minimizes the BEP. Realistic imperfect channel estimation and frequency-domain (FD) block-fading channels are considered. More explicitly, the analytical expression of the optimum PE parameter is derived as a function of the number of subcarriers, number of active users (i.e., the system load), mean signal-to-noise ratio (SNR), and variance of the channel-estimation errors for the aforementioned FD block-fading channel. We show that the choice of the optimal PE technique significantly increases the achievable system load for the given target BEP and BEO

Special Issue: Advances in Vehicular Networks

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Adaptive TORC Detection for MC-CDMA Wireless Systems

Multi carrier code-division multiple access (MC-CDMA) is considered for beyond third generation wireless systems for its effectiveness in the presence of both multipath fading and interference. This paper analyzes MC-CDMA systems adopting an adaptive detection technique based on threshold orthogonality restoring combining (TORC). The mathematical framework here developed allows the evaluation of both the bit error probability and the bit error outage in downlink with perfect and imperfect channel state information and the derivation of the TORC threshold that optimizes the performance. The optimal threshold is analytically derived as a function of the number of subcarriers, the number of active users, and the mean signal-to-noise ratio. This also enables an adaptive variation of the threshold following slow processes fluctuations. Numerical results show very good performance of TORC with optimal threshold comparing with other combining techniques and demonstrate that the optimal threshold changes considering perfect and imperfect channel estimation. Results are shown both in uncorrelated Rayleigh fading as well as in time and frequency correlated fading channels

On the Effect of Combined Equalization for MC-CDMA Systems in Correlated Fading Channels

Equalization techniques are considered in multi carrier-code division multiple access (MC-CDMA) systems to efficiently combine subcarriers contribution and improve the performance. In this paper we analytically investigate a combined equalization technique which consists in performing both pre- equalization at the transmitter and post-equalization at the receiver, by exploiting channel knowledge at both sides. To keep the framework as much general as possible, a parametric partial combining (PC) technique is considered. The analytical framework proposed allows the derivation of the bit error probability in correlated block fading channels and its dependence on the number of subcarriers, the number of active users, the mean signal-to-noise ratio (SNR) averaged over small-scale fading and, above all, the PC parameters, thus allowing the derivation of optimal equalization technique depending on fading levels